Archives
- 2018-07
- 2018-10
- 2018-11
- 2019-04
- 2019-05
- 2019-06
- 2019-07
- 2019-08
- 2019-09
- 2019-10
- 2019-11
- 2019-12
- 2020-01
- 2020-02
- 2020-03
- 2020-04
- 2020-05
- 2020-06
- 2020-07
- 2020-08
- 2020-09
- 2020-10
- 2020-11
- 2020-12
- 2021-01
- 2021-02
- 2021-03
- 2021-04
- 2021-05
- 2021-06
- 2021-07
- 2021-08
- 2021-09
- 2021-10
- 2021-11
- 2021-12
- 2022-01
- 2022-02
- 2022-03
- 2022-04
- 2022-05
- 2022-06
- 2022-07
- 2022-08
- 2022-09
- 2022-10
- 2022-11
- 2022-12
- 2023-01
- 2023-02
- 2023-03
- 2023-04
- 2023-05
- 2023-06
- 2023-07
- 2023-08
- 2023-09
- 2023-10
- 2023-11
- 2023-12
- 2024-01
- 2024-02
- 2024-03
- 2024-04
- 2024-05
-
The NAD dependent protein silent information regulator Sir i
2018-10-24
The NAD-dependent protein silent information regulator 2 (Sir2) is a deacetylase for histones and other proteins and a key regulator of life span in several organisms. Sirtuin (SIRT)1 of the Sirtuin family is the closest homolog of yeast Sir2 in mammals and has critical functions in the regulation o
-
br Results br Discussion We undertook this study
2018-10-24
Results Discussion We undertook this study in an attempt to unravel the epigenetic mechanisms involved in the silencing of the FMR1 gene in fragile X syndrome by the use of a fibroblast line carrying an unmethylated full mutation. There have been several attempts to study epigenetic silencing
-
The analysis of the transcriptome of
2018-10-24
The analysis of the transcriptome of OXM-treated HSPCs was revealing. First, the data showed very clearly that the mRNA levels of mTERT were not different between treated and untreated animals. In vitro studies by others have shown that OXM can enhance telomerase activity through estrogen receptor-m
-
br Experimental Procedures br Author Contributions br Acknow
2018-10-24
Experimental Procedures Author Contributions Acknowledgments Introduction Duchenne muscular dystrophy (DMD) is a severe muscular degenerative disease caused by loss-of-function mutations in the dystrophin gene located on the X chromosome. The dystrophin gene consists of 79 exons, and dis
-
Another question to address is the potential influence of th
2018-10-24
Another question to address is the potential influence of the degree of maturity of prepubertal donor tissue on the success of transplantation. Donor age-dependent differential gene expression and subsequent protein expression have been reported in tissue grafts. This could alter the initial ability
-
The majority of the characterized NETs bind
2018-10-24
The majority of the characterized NETs bind lamins and/or chromatin binding proteins (Harr et al., 2016; Kind et al., 2013; Wong et al., 2014). Chromatin proteins in pluripotent stem mao inhibitor display hyperdynamic plasticity (Chen and Dent, 2014; Meshorer et al., 2006). During differentiation,
-
Collectively we have evaluated the impact
2018-10-24
Collectively, we have evaluated the impact of a MODY5-causing point mutation (S148L) in the HNF1B gene on human pancreas development using a unique human stem cell model. We report molecular phenotypes (up- and down-regulation of pancreatic genes) when HNF1B is increasingly expressed from days 7 to
-
The present study indicated that induction of glutamatergic
2018-10-24
The present study indicated that induction of glutamatergic markers by nucleotides involved the P2Y4-Gq signaling axis. Expression of the P2Y4 nucleotide receptor was transiently augmented in the course of neuronal differentiation of ESCs, which is coincident with the window of nucleotide-induced vG
-
Previous reports have described ESC based differentiation
2018-10-24
Previous reports have described ESC-based differentiation in collagen gels to study the developmental events of vasculogenesis and angiogenesis (Feraud et al., 2001; Hermant et al., 2007). However, these were not optimized for the assessment of more fundamental aspects of vessel induction, patternin
-
Traditionally testing of hPSC lines for gross chromosomal ch
2018-10-24
Traditionally, testing of hPSC lines for gross chromosomal changes employed karyology by chromosome banding of metaphase topotecan Supplier (Amps et al., 2011; Baker et al., 2007). Although karyotyping allows examination of the entire cell genome in a single assay, an often overlooked issue in eval
-
When we compared the in
2018-10-24
When we compared the in vivo MaSC activity using the gold standard mammary fat pad transplant assay, we found the CD24+ CD49fhi SCA-1neg cells had higher stem cell activity than the CD24+ CD49fhi SCA-1+ subset. Although the stem cell activity of the CD24+ CD49fhi SCA-1+ cells was limited (in vitro m
-
In summary our findings indicated that miR promoted the
2018-10-24
In summary, our findings indicated that miR-375 promoted the osteogenic differentiation of hASCs both in vitro and in vivo, and miR-375 targeted DEPTOR to inhibit the activity of AKT signaling during this process. Furthermore, YAP1 together with miR-375 established a negative feedback loop to regula
-
There is a fast growing interest in
2018-10-24
There is a fast-growing interest in microglia, as they are increasingly implicated in neurodegenerative disease, neurodevelopmental disorders, and in neuropathic pain. Our iPSC microglia transcribe key ci-1033 involved in AD, PD, and MND. Several other disease-associated genes, including LRRK2, woul
-
Study of microglia has been largely restricted to non human
2018-10-24
Study of microglia has been largely restricted to non-human models (mostly mouse), since availability of fresh primary human microglia is very limited and they cannot be propagated. Moreover, microglia rapidly lose their unique identity when removed from the ion channel environment and cultured in
-
br After quantization the Laplace Beltrami operator where re
2018-10-24
After quantization, the Laplace-Beltrami operator where , replaces the quadratic form of the momenta (11). In this case, the “kinetic energy” operator has the form The first term in (14) is a “radial” part of the kinetic energy of the Universe similar to the radial part of the kinetic energy
13547 records 899/904 page Previous Next First page 上5页 896897898899900 下5页 Last page